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Báo cáo khoa học: 17b-Hydroxysteroid dehydrogenase type 11 is a major peroxisome proliferator-activated receptor a-regulated gene in mouse intestine

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In order to study the role of peroxisome proliferator-acti-vated receptor ain mouse intestine, its agonist-inducedproteins were identified by peptide mass fingerprinting fol-lowed byNorthern blot analysis using their cDNAs. One ofthe most remarkably induced proteins was identified as17b-hydroxysterol dehydrogenase type 11. Its very rapidinduction by various agonists was most efficient in intestineand then in liver. These findings together with recentlyreported results showing the enzyme family’s wide substratespectrum, including not only glucocorticoids and sex ster-oidsbut alsobileacids, fattyacidsandbranchedchainaminoacids,...
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Báo cáo khoa học: 17b-Hydroxysteroid dehydrogenase type 11 is a major peroxisome proliferator-activated receptor a-regulated gene in mouse intestine

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