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Licensing origins for replication upon completion of mitosisensures genomic stability in cycling cells. Cdt1 was recentlydiscovered as an essential licensing factor, which is inhibitedby geminin. Over-expression of Cdt1 was shown to predis-pose cells for malignant transformation. We show here thatCdt1 is down-regulated at both the protein and RNA levelwhen primary human fibroblasts exit the cell cycle into G0,and its expression is induced as cells re-enter the cell cycle,prior to S phase onset. ...
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Báo cáo khoa học: 3 Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines
