Timtailieu.net 
Phân tích tư tưởng của nhân dân qua đoạn thơ: Những người vợ nhớ chồng… Những cuộc đời đã hóa sông núi ta trong Đất nước của Nguyễn Khoa Điềm
3405
1
0
9 trang
Oxysterols, and particularly 7-ketocholesterol, appear to be stronglyinvolved in the physiopathology of atherosclerosis. These molecules aresuspected to be cytotoxic to the cells of the vascular wall and mono-cytes⁄macrophages, particularly by inducing apoptosis. Previous studieshave demonstrated that 7-ketocholesterol-induced apoptosis is triggered bya sustained increase of cytosolic-free Ca2+, which elicits the mitochondrialpathway of apoptosis by activation of the calcium-dependent phosphatasecalcineurin, leading to dephosphorylation of the ‘BH3 only’ protein BAD....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: 7-Ketocholesterol-induced apoptosis Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways
