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Báo cáo khoa học: A (1fi3)-b-D-glucan recognition protein from the sponge Suberites domuncula Mediated activation of fibrinogen-like protein and epidermal growth factor gene expression

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Sponges (phylum Porifera) live in a symbiotic relationshipwith microorganisms, primarily bacteria. Until now, mole-cular proof for the capacity of sponges to recognize fungi inthe surroundingaqueousmilieuhas not beenavailable.Herewe demonstrate, for the demospongeSuberites domuncula(Porifera, Demospongiae, Hadromerida), a cell surfacereceptor that recognizes (1fi3)-b-D-glucans, e.g. curdlan orlaminarin. This receptor, the (1fi3)-b-D-glucan-bindingprotein, was identified and its cDNA analysed. The genecoding for the 45 kDa protein was found to be upregulatedin tissue after incubationwith carbohydrate. ...
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Báo cáo khoa học: A (1fi3)-b-D-glucan recognition protein from the sponge Suberites domuncula Mediated activation of fibrinogen-like protein and epidermal growth factor gene expression

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