Danh mục

Báo cáo khoa học: A functional polymorphism at the transcriptional initiation site in b2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of b2-glycoprotein I

Số trang: 9      Loại file: pdf      Dung lượng: 254.43 KB      Lượt xem: 7      Lượt tải: 0    
Jamona

Hỗ trợ phí lưu trữ khi tải xuống: 4,500 VND Tải xuống file đầy đủ (9 trang) 0
Xem trước 2 trang đầu tiên của tài liệu này:

Thông tin tài liệu:

Humanb2-glycoprotein I (b2GPI), also known as apolipo-protein H, has been implicated in haemostasis and the pro-duction ofanti-phospholipid antibodies. There is a widerange ofinterindividual variation in b2GPI plasma levelsthat is thought to be under genetic control, but itsmolecularbasis remains unknown. To understand the genetic basis ofb2GPI variation, we analyzed the 5¢ flanking region oftheb2GPIgene for mutation detection by DHPLC and identi-fied a point mutation at the transcriptional initiation site()1CfiA) with a carrier frequency of 12.1%. ...
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: A functional polymorphism at the transcriptional initiation site in b2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of b2-glycoprotein I

Tài liệu được xem nhiều: