Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle
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A multiprotein complex encompassing a transcription regulator, cardiacankyrin repeat protein (CARP), and the calpain 3 protease was identifiedin the N2A elastic region of the giant sarcomeric protein titin. The presentstudy aimed to investigate the function(s) of this complex in the skeletalmuscle. We demonstrate that CARP subcellular localization is controlledby the activity of calpain 3: the higher the calpain 3, the more importantthe sarcomeric retention of CARP.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle
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