Báo cáo khoa học: A novel c-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1
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Nicotine catabolism, linked inArthrobacter nicotinovoransto the presence of the megaplasmid pAO1, leads to the for-mation ofc-N-methylaminobutyrate from the pyrrolidinering of the alkaloid. Until now the metabolic fate ofc-N-methylaminobutyrate has beenunknown. pAO1 carriesa cluster of ORFs with similarity to sarcosine and dimeth-ylglycine dehydrogenases and oxidases, to the bifunctionalenzyme methylenetetrahydrofolate dehydrogenase/cyclo-hydrolase and to formyltetrahydrofolate deformylase.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: A novel c-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: A novel c-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1
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