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Stimulation of glycogen-targeted protein phosphatase 1 (PP1) activity byinsulin contributes to the dephosphorylation and activation of hepatic gly-cogen synthase (GS) leading to an increase in glycogen synthesis. The gly-cogen-targeting subunits of PP1, GLand R5⁄PTG, are downregulated inthe livers of diabetic rodents and restored by insulin treatment. We showhere that the mammalian genePPP1R3Eencodes a novel glycogen-target-ing subunit of PP1 that is expressed in rodent liver.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents
