Báo cáo khoa học: A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin
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Following up on our previous findings that the skin pos-sesses steroidogenic activity from progesterone, we nowshow widespread cutaneous expression of the full cyto-chrome P450 side-chain cleavage (P450scc) system requiredfor the intracellular catalytic production of pregnenolone,i.e. the genes andproteins for P450scc enzyme, adrenodoxin,adrenodoxin reductase and MLN64. Functionality of thesystem was confirmed in mitochondria from skin cells.
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Báo cáo khoa học: A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin
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