Báo cáo khoa học: A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells
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CD40 is areceptorwithnumerous functions in theactivationof antigenpresentingcells (APCs), particularlydendritic cells(DC). Using phage display technology, we identified linearpeptides containing a novel FPGN/S consensus sequencethat enhances the binding of phage to a purified murineCD40-immunoglobulin (Ig) fusion protein (CD40-Ig), butnot to Ig alone. To examine the ability theFPGN/Speptidesto enhance adenoviral infection of CD40-positive cells, weused bifunctional peptides consisting of an FPGN-contain-ing peptide covalently linked to an adenoviral knob-bindingpeptide (KBP)....
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Báo cáo khoa học: A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells
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