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Platelet-activating factor (PAF) is one of the most potentinflammatory mediators. It is biosynthesized by either thede novobiosynthesis of glyceryl ether lipids or by remodelingofmembranephospholipids. PAFis synthesizedandcatabo-lizedbyvarious renal cells andtissues andexerts awide rangeof biological activities on renal tissue suggesting a potentialrole during renal injury. The aimof this studywas to identifywhether cortex and medulla of human kidney contain theacetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyl-transferase (lyso-PAF AT) activity which catalyses the laststep of the remodeling biosynthetic route of PAF and isactivated in inflammatory conditions. ...
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue
