Báo cáo khoa học: Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection
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Class III adenylyl cyclases usually possess six highly conserved catalyticresidues. Deviations in these canonical amino acids are observed in severalputative adenylyl cyclase genes as apparent in several bacterial genomes.This suggests that a variety of catalytic mechanisms may actually exist.The geneRv0386from Mycobacterium tuberculosiscodes for an adenylylcyclase catalytic domain fused to an AAA-ATPase and a helix-turn-helixDNA-binding domain.
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Báo cáo khoa học: Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection
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Báo cáo khoa học: Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection
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