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Báo cáo khoa học: Age-related impairment of mitochondrial matrix aconitase and ATP-stimulated protease in rat liver and heart

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Mitochondrial matrix proteins are sensitive to oxidativeinactivation, and oxidized proteins are known to accumu-late during ageing. The Lon protease is believed to play animportant role in the degradation of oxidized matrix pro-teins such as oxidized aconitase. We reported previouslythat an age-related accumulation of altered proteins occursin the liver matrix of rats and that the ATP-stimulatedproteolytic activity, referred as to Lon-like protease activ-ity, decreases considerably in 27 month-old rats, whereasno concomitant changes in the levels of Lon proteinexpression occur in the liver....
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Báo cáo khoa học: Age-related impairment of mitochondrial matrix aconitase and ATP-stimulated protease in rat liver and heart

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