Báo cáo khoa học: An asymmetric ion channel derived from gramicidin A Synthesis, function and NMR structure
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The biological ion channel gramicidin A (gA) was modified by syntheticmeans to obtain the tail-to-tail linked asymmetric gA-derived dimer com-pound3. Single-channel current measurements for 3in planar lipid bilayersexhibit an Eisenman I ion selectivity for alkali cations. The structuralasymmetry does not lead to an observable functional asymmetry. Thestructure of 3in solution without and with Cs cations was investigated by1H-NMR spectroscopy. In CDCl3⁄CD3OH (1 : 1, v⁄v),3forms a mixtureof double-strandedb-helices....
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Báo cáo khoa học: An asymmetric ion channel derived from gramicidin A Synthesis, function and NMR structure
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Báo cáo khoa học: An asymmetric ion channel derived from gramicidin A Synthesis, function and NMR structure
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