Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein
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The presenilin complex, consisting of presenilin, nicastrin, anterior pharynxdefective-1 and presenilin enhancer-2, constitutes c-secretase, which isrequired for the generation of amyloid b-protein. In this article, we showthat Synoviolin (also called Hrd1), which is an E3 ubiquitin ligase implicatedin endoplasmic reticulum-associated degradation
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Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein
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