Báo cáo khoa học: An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel
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KcsA, a potassium channel fromStreptomyces lividans, was the first ionchannel to have its transmembrane domain structure determined by crystal-lography. Previously we have shown that its C-terminal cytoplasmicdomain is crucial for the thermostability and the expression of the channel.Expression was almost abolished in its absence, but could be rescued bythe presence of an artificial left-handed coiled coil tetramerization domainGCN4.
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Báo cáo khoa học: An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel
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Báo cáo khoa học: An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel
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