Báo cáo khoa học: Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant
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We recently reported that the transient expression of polyglutamine tractsof various size in exon 1 of the huntingtin polypeptide (httEx1) generatedabnormally high levels of intracellular reactive oxygen species that directlycontributed to cell death. Here, we compared the protection generated byheat shock proteins to that provided by the antioxidant agentN-acetyl-l-cysteine.
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Báo cáo khoa học: Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant
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