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The dermal glands of frogs produce antimicrobial peptidesthat protect the skin against noxious microorganisms andassist in wound repair. The sequences of these peptides arevery dissimilar, both within and between species, so that the5000 living anuran frogs may produce100 000 differentantimicrobial peptides. The antimicrobial peptides of SouthAmerican hylid frogs are derived from precursors, thepreprodermaseptins, whose signal peptides and interveningsequences are remarkably conserved, but their C-terminaldomains are markedly diverse, resulting in mature peptideswith different lengths, sequences and antimicrobial spectra....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain
