Báo cáo khoa học: Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber's hereditary optic neuropathy
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Oxidative stress and imbalance between free radical generation and detoxi-fication may play a pivotal role in the pathogenesis of Leber’s hereditaryoptic neuropathy (LHON). Mitochondria, carrying the homoplasmic11778⁄ND4, 3460⁄ND1 and 14484⁄ND6 mtDNA point mutations associ-ated with LHON, were used to generate osteosarcoma-derived cybrids.Enhanced mitochondrial production of reactive oxygen species has recentlybeen demonstrated in these cybrids [Beretta S, Mattavelli L, Sala G, Trem-olizzo L, Schapira AHV, Martinuzzi A, Carelli V & Ferrarese C (2004)Brain127, 2183–2192]. ...
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Báo cáo khoa học: Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber’s hereditary optic neuropathy
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Báo cáo khoa học: Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber’s hereditary optic neuropathy
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