Báo cáo khoa học: Aptamers toEscherichia colicore RNA polymerase that sense its interaction with rifampicin, r-subunit and GreB
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BacterialRNApolymerase (RNAP) is the central enzyme ofgene expression that is responsible for the synthesis of alltypes of cellular RNAs. The process of transcription isaccompanied by complex structural rearrangements ofRNAP. Despite the recent progress in structural studiesof RNAP, detailed mechanisms of conformational changesof RNAP that occur at different stages of transcriptionremain unknown. The goal of this workwas to obtain novelligands to RNAP which would target different epitopes ofthe enzyme and serve as specific probes to study the mech-anism of transcription and conformational flexibility ofRNAP....
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Báo cáo khoa học: Aptamers toEscherichia colicore RNA polymerase that sense its interaction with rifampicin, r-subunit and GreB
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Báo cáo khoa học: Aptamers toEscherichia colicore RNA polymerase that sense its interaction with rifampicin, r-subunit and GreB
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