Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells
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Autophagy and apoptosis have been known to be interconnected positivelyor negatively; however, the molecular mechanisms mediating these two cel-lular processes are not fully understood. In the present study, we demon-strated that the exposure of L929 cells to oridonin led to intracellularreactive oxygen species generation, followed by lipid peroxidation, as wellas decreases in superoxide dismutase and glutathione activities.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells
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