Báo cáo khoa học: Biochemical pharmacology of the vanilloid receptor TRPV1 An update
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There is mounting evidence that the vanilloid (capsaicin)receptor; transient receptor potential channel, vanilloidsubfamily member 1 (TRPV1), is subjected to multipleinteracting levels of control. The first level is by reversiblephosphorylation catalyzed by intrinsic kinases (e.g. proteinkinase A and C) and phosphatases (e.g. calcineurin), whichplays a pivotal role in receptor sensitization vs. tachyphy-laxis. In addition, this mechanism links TRPV1 to intracel-lular signaling by various important endogenous as well asexogenous substances such as bradykinin, ethanol, nicotinand insulin....
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Báo cáo khoa học: Biochemical pharmacology of the vanilloid receptor TRPV1 An update
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Báo cáo khoa học: Biochemical pharmacology of the vanilloid receptor TRPV1 An update
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