Báo cáo khoa hoc : BRICHOS domain associated with lung fibrosis, dementia and cancer – a chaperone that prevents amyloid fibril formation?

REVIEW ARTICLEHanna Willander1,2, EriThe BRICHOS domain was initially defined from sequence alignments ofthe Bri protein associated with familial dementia, chondromodulin associ-ated with chondrosarcoma and surfactant protein C precursor (proSP-C)associated with respiratory distress syndrome and interstitial lung disease(ILD). Today BRICHOS has been found in 12 protein families.k Hermansson2, Jan Johansson1,2 and Jenny Presto1,21 Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden 2 KI-Alzheimer’s Disease Research Center, NVS Department, Karolinska Institutet, Stockholm, SwedenKeywords Alzheimer’s disease; Bri; chaperone; dementia; lung fibrosis, proSP-C, protein misfolding Correspondence J. Presto, KI-Alzheimer’s disease research center, NVS department, Karolinska Institutet, Stockholm, Sweden Fax:...
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Báo cáo khoa hoc : BRICHOS domain associated with lung fibrosis, dementia and cancer – a chaperone that prevents amyloid fibril formation?