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Macrophage colony stimulating factor (M-CSF) or CSF-1 controls thedevelopment of the macrophage lineage through its receptor tyrosine kin-ase, c-Fms. cAMP has been shown to influence proliferation and differenti-ation in many cell types, including macrophages. In addition, modulationof cellular ERK activity often occurs when cAMP levels are raised. Wehave shown previously that agents that increase cellular cAMP inhibitedCSF-1-dependent proliferation in murine bone marrow-derived macro-phages (BMM) which was associated with an enhanced extracellular signal-regulated kinase (ERK) activity....
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Báo cáo khoa học: cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation
