Báo cáo khoa học: Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7
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Caspases are a family of cysteine proteases with roles in cytokine matur-ation or apoptosis. Caspase-2 was the first pro-apoptotic caspase identified,but its functions in apoptotic signal transduction are still being elucidated.This study examined the regulation of the activity of caspase-2 usingrecombinant proteins and a yeast-based system. Our data suggest that forhuman caspase-2 to be active its large and small subunits must be separ-ated. For maximal activity its prodomain must also be removed....
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Báo cáo khoa học: Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7
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Báo cáo khoa học: Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7
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