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Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix

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Aging is accompanied by a gradual deterioration of cellfunctions. Mitochondrial dysfunction and accumulation ofprotein damage have been proposed to contribute to thisprocess. The present study was carried out to examine theeffects of aging in mitochondrial matrix isolated from ratliver. The activity of Lon protease, an enzyme implicated inthe degradation of abnormal matrix proteins, was meas-ured and the accumulation of oxidation and glycoxidation(Ne-carboxymethyllysine, CML) products was monitoredusing immunochemical assays....
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Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix

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