Báo cáo khoa học: Comparison of the solution structures of angiotensin I & II Implication for structure-function relationship
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Conformational analysis of angiotensin I (AI) and II (AII)peptides has been performed through 2D1H-NMRspectro-scopy in dimethylsulfoxide and 2,2,2-trifluoroethanol/H2O.The solution structural models of AI and AII have beendetermined in dimethylsulfoxide using NOE distance and3JHNHacoupling constants. Finally, theAI family of modelsresulting from restrained energy minimization (REM)refinement, exhibits pairwise rmsd values for the familyensemble 0.26 ± 0.13 A˚,1.05 ± 0.23 A˚, for backbone andheavy atoms, respectively, and the distance penalty functionis calculated at 0.075 ± 0.006 A˚2. ...
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Báo cáo khoa học: Comparison of the solution structures of angiotensin I & II Implication for structure-function relationship
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Báo cáo khoa học: Comparison of the solution structures of angiotensin I & II Implication for structure-function relationship
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