Báo cáo khoa học: Complete high-density lipoproteins in nanoparticle corona
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In a biological environment, nanoparticles immediately become covered byan evolving corona of biomolecules, which gives a biological identity to thenanoparticle and determines its biological impact and fate. Previous effortsat describing the corona have concerned only its protein content. Here, forthe first time, we show, using size exclusion chromatography, NMR, andpull-down experiments, that copolymer nanoparticles bind cholesterol, tri-glycerides and phospholipids from human plasma, and that the bindingreaches saturation. ...
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Báo cáo khoa học: Complete high-density lipoproteins in nanoparticle corona
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Báo cáo khoa học: Complete high-density lipoproteins in nanoparticle corona
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