Báo cáo khoa học: Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases
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A complex of chagasin, a protein inhibitor fromTrypanosoma cruzi, andpapain, a classic family C1 cysteine protease, has been crystallized. Kineticstudies revealed that inactivation of papain by chagasin is very fast(kon= 1.5·106m)1Æs)1), and results in the formation of a very tight,reversible complex (Ki =36pm), with similar or better rate and equilib-rium constants than those for cathepsins L and B.
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Báo cáo khoa học: Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases
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medical reports thesis report traditional medicine biochemical studies environmental medicine Crystal structureTài liệu liên quan:
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