Báo cáo khoa học: Cytosolic phospholipase A2-a and cyclooxygenase-2 localize to intracellular membranes of EA.hy.926 endothelial cells that are distinct from the endoplasmic reticulum and the Golgi apparatus
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Cytosolic phospholipase A2-a(cPLA2-a) is a calcium-activated enzyme thatplays an important role in agonist-induced arachidonic acid release. Inendothelial cells, free arachidonic acid can be converted subsequently intoprostacyclin, a potent vasodilator and inhibitor of platelet activation,through the action of cyclooxygenase (COX) enzymes. Here we study therelocation of cPLA2-a in human EA.hy.926 endothelial cells followingstimulation with the calcium-mobilizing agonist, A23187.
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Báo cáo khoa học: Cytosolic phospholipase A2-a and cyclooxygenase-2 localize to intracellular membranes of EA.hy.926 endothelial cells that are distinct from the endoplasmic reticulum and the Golgi apparatus
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Báo cáo khoa học: Cytosolic phospholipase A2-a and cyclooxygenase-2 localize to intracellular membranes of EA.hy.926 endothelial cells that are distinct from the endoplasmic reticulum and the Golgi apparatus
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