Báo cáo khoa học: Deciphering enzymes Genetic selection as a probe of structure and mechanism
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The efficient engineering of enzymes with novel activitiesremains an ongoing challenge. Towards this end, geneticselection techniques provide a method for finding raresolutions to catalytic problems that requires only a limitedforeknowledge of structure–function relationships. Wehave used genetic selections to extensively probe thestructure and mechanism of chorismate mutases. Theinsights gained from these investigations will aid futureenzyme design efforts.
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Báo cáo khoa học: Deciphering enzymes Genetic selection as a probe of structure and mechanism
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Báo cáo khoa học: Deciphering enzymes Genetic selection as a probe of structure and mechanism
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