Báo cáo khoa học: Deciphering the key residues in Plasmodium falciparum b-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein
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The type II fatty acid synthase (FAS) pathway ofPlasmodium falciparumisa validated unique target for developing novel antimalarials, due to itsintrinsic differences from the type I pathway operating in humans.b-Ketoacyl acyl carrier protein (ACP) reductase (FabG) performs theNADPH-dependent reduction ofb-ketoacyl-ACP to b-hydroxyacyl-ACP,the first reductive step in the elongation cycle of fatty acid biosynthesis.
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Báo cáo khoa học: Deciphering the key residues in Plasmodium falciparum b-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein
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Báo cáo khoa học: Deciphering the key residues in Plasmodium falciparum b-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein
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