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Báo cáo khoa học: Dehydroepiandrosterone inhibits the proliferation of human umbilical vein endothelial cells by enhancing the expression of p53 and p21, restricting the phosphorylation of retinoblastoma protein, and is androgen- and estrogenreceptor independent

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Dehydroepiandrosterone (DHEA), a steroid hormone, modified the proli-feration of human umbilical vein endothelial cells in a dose-dependentmanner. Its inactive sulfate ester (DHEA-S) and two of its metabolites –estradiol and testosterone – had no inhibitory effect at physiologicalconcentrations. Antiproliferation was associated with arrest in the G1phase of the cell cycle, but not with cell death, as evaluated by cleavageof poly(ADP-ribose) polymerase and exposure of phosphatidylserine. ...
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Báo cáo khoa học: Dehydroepiandrosterone inhibits the proliferation of human umbilical vein endothelial cells by enhancing the expression of p53 and p21, restricting the phosphorylation of retinoblastoma protein, and is androgen- and estrogenreceptor independent

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