Báo cáo khóa học: Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates
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The reactive site loop of serpins undoubtedly defines in parttheir ability to inhibit a particular enzyme. Exchanges inthe reactive loop of serpins might reassign the targets andmodify the serpin–protease interaction kinetics. Based onthis concept, we have developed a procedure to change thespecificity of known serpins. First, reactive loops are verygood substrates for the target enzymes. Therefore, we haveused the phage-display technology to select from a penta-peptide phage library the best substrates for the humanprostatekallikreinhK2 ...
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Báo cáo khóa học: Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates
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Báo cáo khóa học: Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates
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