Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression
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Expression of the tissue inhibitor ofmetalloproteinases-1(Timp-1) gene canbe induced by either phorbol myristate acetate (PMA) or transforminggrowth factorb1 (TGF-b1), although the signalling pathways involved arenot clearly defined. Canonically, histone deacetylase inhibitors (HDACi)such as trichostatin A (TSA) or sodium butyrate (NaB) increase totalcellular histone acetylation and activate expression of susceptible genes.Remarkably, PMA and TGF-b1 stimulation ofTimp-1show a differentialresponse to TSA or NaB. ...
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Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression
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