Báo cáo khoa học: Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein
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We investigated the differential role of protein kinase C(PKC) isoforms in the regulated proteolytic release ofsoluble amyloid precursor protein (sAPPa)inSH-SY5Yneuroblastoma cells. We used cells stably transfected withcDNAs encoding either PKCaor PKCein the antisenseorientation, producing a reduction of the expression ofPKCa and PKCe, respectively. Reduced expression ofPKCaand/or PKCedid not modify the response of thekinase to phorbol ester stimulation, demonstrating translo...
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein
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Report medicine traditional medicine scientific reports medicine cell proliferation oxidationTài liệu liên quan:
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