Báo cáo khoa học: Dimerization of mammalian adenylate cyclases Functional, biochemical and ¯uorescence resonance energy transfer (FRET) studies
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Mammalian adenylate cyclases are predicted to possesscomplex topologies, comprising two cassettes of six trans-membrane-spanningmotifs followedbyacytosolic, catalyticATP-binding domain. Recent studies have begun to provideinsights on the tertiary assembly of these proteins; crystal-lographic analysis has revealed that the two cytosolicdomains dimerize to forma catalytic core, whilemore recentbiochemical and cell biological analysis shows that the twotransmembrane cassettes also associate to facilitate thefunctional assembly and trackingof the enzyme. ...
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Báo cáo khoa học: Dimerization of mammalian adenylate cyclases Functional, biochemical and ¯uorescence resonance energy transfer (FRET) studies
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Dimerization of mammalian adenylate cyclases Functional, biochemical and ¯uorescence resonance energy transfer (FRET) studies
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