Phân tích tư tưởng của nhân dân qua đoạn thơ: Những người vợ nhớ chồng… Những cuộc đời đã hóa sông núi ta trong Đất nước của Nguyễn Khoa Điềm
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Rogers syndrome is an autosomal recessive disorder result-ing in megaloblastic anemia, diabetes mellitus, and sensori-neural deafness. The gene associated with this diseaseencodes for thiamine transporter 1 (THTR1), a member ofthe SLC19 solute carrier family including THTR2 and thereduced folate carrier (RFC). Using transient transfectionsinto NIH3T3 cells of a D93H mutant THTR1derivedfrom a Rogers syndrome family, we determined theexpression, post-translational modification, plasma mem-brane targeting and thiamine transport activity. We alsoexplored the impact on methotrexate (MTX) transportactivity of a homologous missense D88H mutation in thehuman RFC, a close homologue of THTR1....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Disruption of transport activity in a D93H mutant thiamine transporter 1, from a Rogers Syndrome family
