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Intracellular heme concentrations are maintained in part by heme degrada-tion, which is catalyzed by heme oxygenase. Heme oxygenase consists oftwo structurally related isozymes, HO-1 and HO-2. Recent studies haveidentified HO-2 as a potential oxygen sensor. To gain further insights intothe regulatory role of HO-2 in heme homeostasis, we analyzed the expres-sion profiles of HO-2 and the biochemical consequences of HO-2 knock-down with specific short interfering RNA (siRNA) in human cells.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines
