Báo cáo khoa học: Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human a-tropomyosin
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Mutations in the proteina-tropomyosin (Tm) can cause adisease known as familial hypertrophic cardiomyopathy. Inorder to understand how such mutations lead to proteindysfunction, three point mutations were introduced intocDNA encoding the human skeletal tropomyosin, and therecombinant Tms were produced at high levels in the yeastPichia pastoris. Two mutations (A63V and K70T) werelocated in theN-terminal regionofTmandone (E180G)waslocated close to the calcium-dependent troponin T bindingdomain....
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Báo cáo khoa học: Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human a-tropomyosin
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Báo cáo khoa học: Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human a-tropomyosin
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