Báo cáo khoa học: Emerging pathways in genetic Parkinson's disease: Autosomal-recessive genes in Parkinson's disease – a common pathway?
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Rare, inherited mutations causing familial forms of Parkinson’s diseasehave provided insight into the molecular mechanisms that underlie thegenetic and sporadic forms of this disease. Loss of protein function result-ing from autosomal-recessive mutations in PTEN-induced putative kinase 1(PINK1), Parkin and DJ-1 has been linked to mitochondrial dysfunction,accumulation of abnormal and misfolded proteins, impaired protein clear-ance and oxidative stress.
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Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway?
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Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway?
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