Báo cáo khoa học: Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells
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We have previously reported the Ras-dependent activation of the mitogen-activated protein kinases p44 and p42, also termed extracellular signal-regulated kinases (ERK)1 and 2 (ERK1⁄2), mediated through Gs-coupledserotonin receptors transiently expressed in human embryonic kidney(HEK) 293 cells. Whereas Gi- and Gq-coupled receptors have been shownto activate Ras through the guanine nucleotide exchange factor (GEF)called Ras-GRF1 (CDC25Mm) by binding of Ca2+⁄calmodulin to itsN-terminal IQ domain, ...
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Báo cáo khoa học: Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells
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Báo cáo khoa học: Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells
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