Báo cáo khoa học: Endogenous mono-ADP-ribosylation mediates smooth muscle cell proliferation and migration via protein kinase N-dependent induction of c-fos expression
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ADP-ribosylation has been coupled to intracellular eventsassociated with smooth muscle cell vasoreactivity, cytoskel-etal integrity and free radical damage. Additionally, there isevidence that ADP-ribosylation is required for smoothmuscle cell proliferation. Our investigation employedselective inhibitors to establish thatmono-ADP-ribosylationand not poly(ADP-ribosyl)ation was necessary for the sti-mulationofDNAsynthesis bymitogens.
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Báo cáo khoa học: Endogenous mono-ADP-ribosylation mediates smooth muscle cell proliferation and migration via protein kinase N-dependent induction of c-fos expression
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Endogenous mono-ADP-ribosylation mediates smooth muscle cell proliferation and migration via protein kinase N-dependent induction of c-fos expression
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