Báo cáo khoa học: Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA
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Although allostery plays a central role in driving protein–DNA interac-tions, the physical basis of such cooperative behavior remains poorlyunderstood. In the present study, using isothermal titration calorimetry inconjunction with site-directed mutagenesis, we provide evidence that anintricate network of energetically-coupled residues within the basic regionsof the Jun-Fos heterodimeric transcription factor accounts for its allostericbinding to DNA.
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Báo cáo khoa học: Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA
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Báo cáo khoa học: Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA
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