Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703
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Tumour necrosis factor-related apoptosis-inducing ligand(TRAIL) has attractedmuch attention because of its abilityto kill tumour cells. In this study, we demonstrated thattreatment of QGY-7703 cells with the combination ofTRAIL and etoposide resulted in synergistic cytotoxiceffects. In dissecting the mechanism underlying this syner-gistic effect, we found that treatment with etoposide aloneresulted in the upregulation of Bax, while the level of trun-catedBid (tBid)wasunchanged.
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Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703
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