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The retinal pigment epithelium (RPE) is essential for main-tenance of photoreceptors and normally functions underconditions enriched with reactive oxygen species. RPEtherefore expresses various defense enzymes against oxida-tive stress, including heme oxygenase-1 (HO-1). HO-1catalyzes heme breakdown to release iron, carbon monox-ide, and biliverdin, which is reduced to bilirubin, a potentradical scavenger. HO-1 expression is induced by variousenvironmental factors, which has been established as a def-ense mechanism....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Expression of heme oxygenase-1 is repressed by interferon-c and induced by hypoxia in human retinal pigment epithelial cells
