Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis
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Plasmin(ogen) kringles 1 and 4 are involved in anchorage of plasmin(ogen)to fibrin and cells, an essential step in fibrinolysis and pericellular proteo-lysis. Their contribution to these processes was investigated by selectiveneutralization of their lysine-binding function. Blocking the kringle 1 lysine-binding site with monoclonal antibody 34D3 fully abolished binding andactivation of Glu-plasminogen and prevented both fibrinolysis and plasmin-induced cell detachment-induced apoptosis.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis
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