Báo cáo khoa học: G1–Molecular Chaperones
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Misfolded proteins, aggregates, and inclusion bodies are hall-marks of the cytopathology of neurodegenerative disordersincluding Huntington’s disease, Amyotropic lateral sclerosis,Parkinson’s disease, Prion diseases, and Alzheimer’s disease.The appearance of proteins with altered folded states is regula-ted by the protein folding quality control machinery and age-dependent. We have identified an unexpected molecular linkbetween metabolic state, accumulation of damaged proteins, theheat-shock response and chaperones, and longevity....
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Báo cáo khoa học: G1–Molecular Chaperones
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Báo cáo khoa học: G1–Molecular Chaperones
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