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Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3

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10.10.2023

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The immune coagulant fgl2/fibroleukin has been previouslyshown to play a pivotal role in the pathogenesis of murineand human fulminant hepatitis and fetal loss syndrome.Constitutive expression of fgl2 transcripts at low levels areseen in cytotoxic T cells, endothelial, intestinal and tropho-blast cells, while specific factors (such as virus and cytokines)are required to induce high levels of fgl2 expression in othercell types including monocytes/macrophages. To addressthe transcriptional mechanisms that regulate constitutiveexpressionof fgl2,murinegenomic cloneswere characterizedand the transcription start site was defined by 5¢-RACE andprimer extension. ...
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Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3

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