Báo cáo khoa học: Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5¢-phosphate oxidase
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We used a combined computer and biochemical approachto characterize human pyridoxine 5¢-phosphate oxidase(PNPO).The human PNPOgene is composed of sevenexons and six introns, and spans approximately 8 kb.Allexon/intron junctions contain the gt/ag consensus splicingsite.The absence of TATA-like sequences, the presence ofSp1-binding sites and more importantly, the presence ofCpG islands in the regulatory region of thePNPOgene arecharacteristic features of housekeeping genes.
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Báo cáo khoa học: Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5¢-phosphate oxidase
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Báo cáo khoa học: Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5¢-phosphate oxidase
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